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| 1526 | Declaration of War Charles V |  |
| Fought between the Habsburg Charles V, Spain and the Holy Roman Empire, & the League of Cognac, an Alliance including France, Pope Clement VII, the Republic of Venice, England, the Duchy of Milan & Florence |
| 1526 | Invasion of Lombardy Charles V | |
| Lombardy The League of Cognac quickly seizes Lodi, but Imperial troops march into Lombardy and soon force Sforza to abandon Milan |
| 1527 | Invasion of Rome Charles V | |
| Rome Charles V gathers a force of landsknechts under Georg Frundsberg and a Spanish army under Charles of Bourbon, the two forces combine at Piacenza and advance on Rome |
| Rome Francesco Guicciardini, in command of the Papal armies, proves unable to resist and when the Duke of Bourbon is killed, his underpaid army sack the city, forcing the Pope to flee |
| 1527 | Invasion of Rome Guicciardini, Francesco | |
| Rome Francesco Guicciardini, in command of the Papal armies, proves unable to resist and when the Duke of Bourbon is killed, his underpaid army sack the city, forcing the Pope to flee |
| 1526 | League of Cognac Charles V | |
| Fought between the Habsburg Charles V, Spain and the Holy Roman Empire, & the League of Cognac, an Alliance including France, Pope Clement VII, the Republic of Venice, England, the Duchy of Milan & Florence |
| Shocked by the defeat of the French in the Italian War of 1521, Clement, together with the Republic of Venice, organizes an Alliance to drive the Habsburg powers-Spain and the Holy Roman Empire-from Italy |
| 1526 | Siege of Milan Charles V | |
| Milan The League of Cognac quickly seizes Lodi, but Imperial troops march into Lombardy and soon force Sforza to abandon Milan |
| 1529 | Treaty of Barcelona Charles V | |
| 29th June Barcelona Francis surrenders his rights to Artois, Flanders, and Tournai, and is obliged to pay a ransom of two million golden ‚cus before his sons were to be released |
| 29th June Barcelona Signs a treaty with Pope Clement VII settling their differences |
| 5th Aug Barcelona The final treaty, signed on August 5, removes France from the war, leaving Venice, Florence, and the Pope alone against Charles |
