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| Alliance Charles V |  |
| Rome The Alliance of the League of Cognac is defeated by Charles V |
| Birth of Philip II Philip II | |
| 21st April Valladolid Birth of Philip II |
| Invasion of Rome Charles V | |
| Rome Charles V gathers a force of landsknechts under Georg Frundsberg and a Spanish army under Charles of Bourbon, the two forces combine at Piacenza and advance on Rome |
| Rome Francesco Guicciardini, in command of the Papal armies, proves unable to resist and when the Duke of Bourbon is killed, his underpaid army sack the city, forcing the Pope to flee |
| Invasion of Rome Guicciardini, Francesco | |
| Rome Francesco Guicciardini, in command of the Papal armies, proves unable to resist and when the Duke of Bourbon is killed, his underpaid army sack the city, forcing the Pope to flee |
| Siege of Rome Charles V | |
| Rome Clement VII begs Charles V but it is too late to save Rome |
| Rome Clement VII & Charles V sign a truce |
| Rome Rome & the Vatican are sacked by German Lutheran forces & a council is called |
| Rome The Alliance of the League of Cognac is defeated by Charles V |
