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| Capture of Artois Charles V |  |
| 14th Jan Artois Gains Artois from France |
| Capture of Burgundy Charles V | |
| 14th Jan Burgundy Gains Burgundy from France |
| Capture of Flanders Charles V | |
| 14th Jan Artois Gains Flanders from France |
| Colonization Florida Ayllon, Lucas Vasquez de | |
| Florida Leaves Santo Domingo with settlers to found a colony in Florida |
| Colonization Sth Carolina Ayllon, Lucas Vasquez de | |
| South Carolina Helps colonize Sth Carolina at Winyah Bay |
| Death of Vasquez de Ayllon, Lucas Vasquez de Ayllon, Lucas | |
| 18th Oct Santo Domingo Fails in an attempt to found a colony in Florida, the settlers return to Santo Domingo |
| Declaration of War Charles V | |
| Allied with the Pope, Bavaria & Protestant Princes |
| Fought between the Habsburg Charles V, Spain and the Holy Roman Empire, & the League of Cognac, an Alliance including France, Pope Clement VII, the Republic of Venice, England, the Duchy of Milan & Florence |
| Invasion of Hungary Charles V | |
| Turkey captures most of Hungary |
| Invasion of Lombardy Charles V | |
| Lombardy The League of Cognac quickly seizes Lodi, but Imperial troops march into Lombardy and soon force Sforza to abandon Milan |
| League Cognac Charles V | |
| 22nd May Cognac The League of Cognac is formed against Charles V |
| 22nd May Cognac The League of Cognac is formed with the Pope, Milan, Venice, & Florence |
| 22nd May Madrid Francis I renounces the Treaty of Madrid as it was made under duress |
| League of Cognac Charles V | |
| Fought between the Habsburg Charles V, Spain and the Holy Roman Empire, & the League of Cognac, an Alliance including France, Pope Clement VII, the Republic of Venice, England, the Duchy of Milan & Florence |
| Shocked by the defeat of the French in the Italian War of 1521, Clement, together with the Republic of Venice, organizes an Alliance to drive the Habsburg powers-Spain and the Holy Roman Empire-from Italy |
| Marriage of Charles V Charles V | |
| Marries Isabella of Portugal |
| Rule of Artois Charles V | |
| 14th Jan Artois Under the treaty of Madrid Francis surrenders Burgundy, Artois & Flanders to Charles V |
| Rule of Burgundy Charles V | |
| 14th Jan Burgundy Under the treaty of Madrid Francis surrenders Burgundy, Artois & Flanders to Charles V |
| Rule of Flanders Charles V | |
| 14th Jan Flanders Under the treaty of Madrid Francis surrenders Burgundy, Artois & Flanders to Charles V |
| Rule of Peru Almargo, Diego de | |
| Pizarro & Almagro lead an expedition to Peru, 1526-1527 |
| Rule of Peru Pizarro, Francisco | |
| Pizarro & Almagro lead an expedition to Peru, 1526-1527 |
| Siege of Milan Charles V | |
| Milan The League of Cognac quickly seizes Lodi, but Imperial troops march into Lombardy and soon force Sforza to abandon Milan |
| Treaty of Cognac Charles V | |
| Cognac Allies Rome, Venice, the Pope & France against Charles V |
| Treaty of Madrid Charles V | |
| 14th Jan Madrid Under the treaty of Madrid Francis gives up all claims in Italy |
| 14th Jan Madrid Under the treaty of Madrid Francis surrenders Burgundy, Artois & Flanders to Charles V |
