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| 1045 | Sylvester III |  |
| Sylvester III recognizes Gregory VI as Pope |
| 1874 | Minghetti, Marco | |
| 25th May Minghetti resigns from office but the King refuses to accept |
| 1919 | Orlando, Vittorio Emmanuele | |
| 20th June Resigns after Woodrow Wilson refuses to recognize his territorial demands |
| 1922 | Facta, Luigi | |
| 28th Oct Fails to get Victor Emmanuel to agree to martial law & resigns |
| 1925 | Orlando, Vittorio Emmanuele | |
| Resigns after the Fascist electoral fraud |
| 1940 | Badoglio, Pietro | |
| Resigns after Italy's failure in Abysinnia |
| Resigns after the disastrous campaign in Greece |
| 1943 | Ambrosio, Vittorio | |
| July Feltre Resigns after Mussolini's meeting with Hitler |
| 1943 | Ciano | |
| Vatican "Exiled" to the Vatican as Mussolini's Ambassadoor |
| Resigns after Germany's defeat in Russia & failure to persuade Mussolini to make peace |
| 1943 | Ciano, Galeazzo | |
| Vatican "Exiled" to the Vatican as Mussolini's Ambassadoor |
| Resigns after Germany's defeat in Russia & failure to persuade Mussolini to make peace |
| 1943 | Mussolini, Benito Amilicare Andrea | |
| 25th July Victor Emmanuel, Badogli & the Grand Council force Mussolini's resignation |
| 1976 | Moro, Aldo | |
| 6th Jan Resigns after a newspaper says the Party Secretary was not consulted about reflation |
| 1981 | Frolani, Arnaldo | |
| 26th May Resigns after top officials are linked to the "P2" masonic lodge |
| 1987 | Craxi, Bettino | |
| 1st Mar Rome Resigns after 3 1/2 yrs in office, the longest government in Italy since World War II |
| 1991 | Andreotti, Giulio | |
| 29th Mar Rome Forced to resign by the Socialist Party |
| 1994 | Berlusconi, Silvio | |
| Dec Rome Resigns rather than lose a no confidence vote |
| 1996 | Dini, Lamberto | |
| 11th Jan Rome Announces his resignation |
| 1997 | Prodi, Romano | |
| Rome Resigns as the Prime Minister of Italy |
| 2007 | Prodi, Romano | |
| 28th Feb Prodi remains in power, as the Senate narrowly passes a vote of confidence in the prime minister's weak government |
| 28th Feb Romano Prodi submits his resignation after a measure about deploying more troops to Afghanistan and allowing the USAto expand a military base in Italy fails in the Senate, he has been in power only nine months. |
